Hypoxic changes in rat locus coeruleus neurons in vitro.
نویسندگان
چکیده
منابع مشابه
Local opiate withdrawal in locus coeruleus neurons in vitro.
Noradrenergic neurons of the brain nucleus locus coeruleus (LC) become hyperactive during opiate withdrawal. It has been uncertain to what extent such hyperactivity reflects changes in intrinsic properties of these cells. The effects of withdrawal from chronic morphine on the activity of LC neurons were studied using intracellular recordings in rat brain slices. LC neurons in slices from chroni...
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The response of neonatal rat locus coeruleus neurons to contact with myelin extracts prepared from the CNS and PNS was examined. The growth cones of these neurons collapsed following contact with central myelin, but continued to elongate on contact with peripheral myelin. Central myelin elicited an increase in the intracellular free calcium concentration in these growth cones, while peripheral ...
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Studies have shown that following opiate withdrawal, the spontaneous discharge rate of locus coeruleus (LC) neurons remarkably increases. Combination of intrinsic mechanisms with extrinsic excitatory modulations mediates the withdrawal-induced hyperactivity of LC neurons. The nucleus paragigantocellularis (PGi) provides the main excitatory inputs to LC and plays a pivotal role in opiate withdra...
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The GANE (glutamate amplifies noradrenergic effects) model proposed by Mather et al. attempts to explain how norepinephrine enhances processing in highly activated brain regions. Careful perusal of the sparse data available from recording studies in animals reveals that noradrenergic neurons are excited mainly by any change in the environment - a salient, novel, or unexpected sensory stimulus o...
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Locus coeruleus neurons in brain slices prepared from neonatal rats have rhythmic oscillations in membrane potential at frequencies ranging from 0.3 to 3 Hz. Recordings from pairs of neurons separated by 50-300 pm showed that this oscillatory activity was synchronized at ages less than 24 d. Slices cut from rats 24-27 d old showed rhythmic activity which was only partially synchronous between c...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1995
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1995.sp020788